Letrozole is the main substance in the brand name Femara – the most popular brand. But can be sold as numerous other brands. This is an orally active medication that is considered an anti cancer drug. That’s by considering that is mainly used in medical settings for treating hormonally positive (ER+) breast cancer. Mostly used in postmenopausal women after surgery.
- Nonetheless, this medication is actually classified as an Anti-Estrogen and more specifically is in the class of drugs known as Aromatase Inhibitors (AIs).
This is the same class of drugs as Arimidex (Anastrozole) and Aromasin (Exemestane). These types of Anti-Estrogens known as AIs are very different from the other types of Anti-Estrogens known as Selective Estrogen Receptor Modulators (SERMs) such as Clomid (Clomiphene) and Nolvadex (Tamoxifen).
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They are all Anti Estrogens because they are all known to deal with estrogen related issues. But they are very different in how they deal with estrogen and the overall mechanism of action.
Explaining Letrozole
Femara – Letrozole is a non steroidal as well as non suicidal aromatase inhibitor (AI). It belongs to the third generation line of AIs. Letrozole is similar to Anastrozole, they both lower estrogen levels very effectively and both are used for pretty much the same purposes in medical settings. Same uses in physique and performance enhancement settings too.
- However, Letrozole is considered by far the most powerful AI out there. Is capable of reducing estrogen levels more than any other compound out there.
Nowadays, Letrozole is used in medical settings for various needs, mostly for treating breast cancer in females. That’s why it is considered an anti cancer drug. It is also an anti gyno medication and is sometimes given to men to treat gynecomastia. Sometimes might be used for improving sperm count in men. Can be given to women for inducing ovulation too.
Nonetheless, in physique and performance enhancement settings (bodybuilding stages), Letrozole is used due to its estrogen controlling and reducing properties. They are very important to those men who are running anabolic steroids. Specifically aromatized steroids such as testosterones, nandrolones, Dianabol and others are capable of converting into estrogen. This is because they cause high estrogen levels and side effects.
Femara – Letrozole or other AIs are used during the cycle of such steroids in order to lower down the estrogen within the normal levels. Therefore, effectively control the issues that may appear as a result of high estrogen levels. Such as gynecomastia, high blood pressure, bloating, water retention, and many others.
Letrozole Dosage
If you’re being prescribed Letrozole (Femara) for whatever health condition, we highly recommend you to use it exactly as is prescribed by your doctor. Do not administer it in any other way than the one recommended.
If you need Letrozole for physique and performance enhancement – to control estrogen levels during the cycle of steroids, then no doctor would help you with those needs. Unfortunately.
The good news is that you are highly unlikely to need such high doses of Letrozole as a woman might be prescribed for breast cancer treatment. Usually, that’s 2.5 mg per day (one full tablet).
Letrozole dosage for men, to control estrogen levels, usually starts at 0.25 mg up to about 1 mg per day or even every other day.
That’s a good starting dosage. If you would need more, you can increase. But never increase too much because it may lead to highly suppressed estrogen levels and side effects.
Letrozole Side Effects
Usually, the side effects of Letrozole is a sign that you use too high doses and therefore have too suppressed levels of estrogen. This is a very important hormone and if you suppress it too much that’s leading to nasty symptoms.
Estrogen is helpful for:
- Healthy cholesterol levels
- Healthy mineralization of bones
- Essential for Central Nervous System (CNS)
- Various other purposes
Therefore, you may get Letrozole side effects like:
- Negative cholesterol values
- Cardiovascular issues
- Dry/ painful joints
- Osteoporosis
- Fatigue
- Weakness
- Low libido
- Inability to get or maintain an erection
- Inability to grow muscles and gain strength
- Many others
The good news is that most men using it during the cycle of anabolic steroids are very unlikely to get any side effects as they can tolerate the product very well, as long as it is used properly.
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